Innovate with modern sequence design and analysis
Intelligent molecular biology design software for scientists
Increase throughput
Design and analyze sequences at scale with bulk cloning, alignment, and translation tools.
Reveal more insights
Model and optimize sequences by applying the latest algorithms and advanced in silico design tools to guide experimental work.
Collaborate on sequence design
Leverage Benchling to standardize sequence analysis and registration across teams while improving hand-offs and reducing redundancy of work.
Intuitive sequence visualization
Create contextual views of the biomolecules or entities you're developing — DNA, RNA, amino acid sequences as well as oligos with or without chemical modifications.
Choose detailed maps, including plasmid or linear formats to better visualize sequences.
Designate and document annotations, ORFs, primer and restriction enzyme sites to generate a more informative sequence view.
Comprehensive sequence design tools
Import DNA and RNA in bulk from popular public databases into Benchling.
Perform restriction cloning, Gibson assembly, and Golden Gate assembly — all assisted with a guided wizard.
Simulate bulk cloning methods such as restriction enzyme digestion, Gibson assembly or homologous alignment to develop efficient cloning strategies and predict outcomes.
Perform in silico design of chemically modified RNA and mRNA molecules.
View translation of constructed DNA sequences.
Perform back-translation of proteins to infer modifications and better optimize sequence design.
Optimize DNA and RNA primers with a step-by-step design wizard.
Design CRISPR guide RNAs with on-/off-target scoring.
Intelligent sequence analysis
Query Benchling internally using BLASTn and BLASTp to find and characterize sequences
Predict and visualize 3-dimensional protein structures using AlphaFold2
Annotate sequences with shared defined libraries
Automatically compute biochemical properties for any sequence
Annotate amino acid sequences with antibody-specific information, including framework and complementary-determining regions
Perform a single alignment or many alignments in bulk using an expanded set of algorithms
Standardized registration
Ensure sequence uniqueness during registration.
Detect and automatically link registered DNA / RNA parts such as promoter regions to full DNA / RNA sequences.
Centralize experimental and analytical data automatically against registered sequences.
End-to-end sequence traceability
Compare biological entities and specific regions to help model interdependent relationships.
Maintain version history to identify or restore changes to sequence outputs.
Define access controls and role-based permissions for clear accountability and improved collaboration between teams
Perform advanced searches to find sequences and related results across projects and teams
"We did an exhaustive search and selected Benchling, not just because of our own impressions, but also from those of many of our friends working in the industry. Not only was Benchling's molecular biology functionality far and above better than any other we had ever used before but having a single database that could aggregate all our data allows us to do better experiments, to ask better questions, to solve problems more quickly in a way that gets us more value per experiment."
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