Haynes Lab


Arizona State University

Joined in August 2013



16 sequences

modified Apr 03 at 10:34pm

created Aug 04, 2013

hayneslab / Mammalian Basic Parts

Parts used to assemble composites

7 sequences

modified Apr 04 at 08:00pm

created Apr 03, 2014

hayneslab / Synthetic Chromatin Actuators

This unique class of transcription factors (gene activators) are fusion proteins that bind to histone marks (H3K27me3) instead of DNA sequences. The first generation of these actuators, called Pc-TFs, was published by Haynes and Silver in 2011. All proteins listed here are tagged with the mCherry red fluorescent protein for easy visualization, tagged with the myc epitope for biochemical analysis, and placed under control of a Tet repressible (dox-inducible) promoter.
Haynes, K. A., & Silver, P. A. (2011). Synthetic reversal of epigenetic silencing. The Journal of biological chemistry, 286(31), 27176–27182. doi:10.1074/jbc.C111.229567

3 sequences

modified Feb 12 at 07:23pm

created Aug 04, 2013

hayneslab / Vectors for Mammalian Expression

DNA plasmid vectors for expression of synthetic genes in mammalian cells.